Mogi G
Ann Otol Rhinol Laryngol. 1976 Mar-Apr;85(2 Suppl 25 Pt 2):97-102. doi: 10.1177/00034894760850S219.
Secretory IgA (SIgA) was isolated from pooled middle ear effusions (MEE) and its antigenicity and subunit structure were found to be identical to those of SIgA in saliva, nasal secretion and colostrum. The calculated percentage of SIgA in the total IgA of effusions was approximately 11%. Although the SIgA antibodies against streptolysin and staphylolysin were very low when compared to that of IgG class in effusion, this finding confirmed that MEE is at least partially a result of local immunologic reactions. The IgE concentration did not become elevated in both the MEE and serum obtained from patients with otitis media with effusion. Specific reaginic activity against mites was found in 5 of 56 (8.9%) MEE. Our findings would not suggest the significant role of atopic allergy in the formation of MEE.
从合并的中耳积液（MEE）中分离出分泌型IgA（SIgA），发现其抗原性和亚基结构与唾液、鼻分泌物和初乳中的SIgA相同。计算得出积液中总IgA中SIgA的百分比约为11%。尽管与积液中IgG类抗体相比，针对链球菌溶血素和葡萄球菌溶血素的SIgA抗体非常低，但这一发现证实中耳积液至少部分是局部免疫反应的结果。在分泌性中耳炎患者的中耳积液和血清中，IgE浓度均未升高。在56份中耳积液中有5份（8.9%）发现了针对螨虫的特异性反应素活性。我们的研究结果并不表明特应性过敏在中耳积液形成中起重要作用。
