头孢噻吩对大鼠肾皮质庆大霉素浓度的影响。
Effect of cephalothin on renal cortical concentrations of gentamicin in rats.
作者信息
Dellinger P, Murphy T, Barza M, Pinn V, Weinstein L
出版信息
Antimicrob Agents Chemother. 1976 Apr;9(4):587-8. doi: 10.1128/AAC.9.4.587.
Abstract
Renal cortical concentrations of gentamicin were significantly lower in rats given this aminoglycoside and cephalothin simultaneously than in animals given gentamicin alone. This effect may be responsible, in part, for the reduction in nephrotoxicity reported previously in animals given the combination of drugs.
摘要
同时给予庆大霉素和头孢噻吩的大鼠，其肾皮质中庆大霉素的浓度显著低于单独给予庆大霉素的动物。这种效应可能部分导致了先前报道的给予联合用药的动物肾毒性降低。
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本文引用的文献
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Nephrotoxicity of gentamicin.庆大霉素的肾毒性
Lab Invest. 1974 Jan;30(1):48-57.
2
Editorial: Intrarenal antibiotic distribution in health and disease.社论：健康与疾病状态下肾脏内抗生素的分布
Kidney Int. 1974 Sep;6(3):131-7. doi: 10.1038/ki.1974.91.
3
Renal parenchymal accumulation of aminoglycoside antibiotics in rats.大鼠肾实质中氨基糖苷类抗生素的蓄积
J Infect Dis. 1974 Dec;130(6):656-9. doi: 10.1093/infdis/130.6.656.
4
Protective effect of cephalothin against gentamincin-induced nephrotoxicity in rats.头孢噻吩对庆大霉素诱导的大鼠肾毒性的保护作用。
Antimicrob Agents Chemother. 1976 Jan;9(1):172-8. doi: 10.1128/AAC.9.1.172.
5
Gentamicin nephrotoxicity: failure of three cephalosporins to potentiate injury in rats.庆大霉素肾毒性：三种头孢菌素未能增强大鼠肾损伤
Antimicrob Agents Chemother. 1975 Aug;8(2):209-15. doi: 10.1128/AAC.8.2.209.
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Predictability of blood levels of gentamicin in man.庆大霉素在人体中的血药浓度可预测性。
J Infect Dis. 1975 Aug;132(2):165-74. doi: 10.1093/infdis/132.2.165.
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