Buys H, Hendricks M, Eley B, Hussey G
Child Health Unit, 46 Sawkins Road, Rondebosch, 7700, Cape Town.
SADJ. 2002 Dec;57(11):454-6.
It has been postulated that micronutrients play a role in the pathogenesis of HIV disease. Though data are sparse, there is evidence that HIV-infected adults and children have a range of micronutrient deficiencies with increasing severity in advanced disease and in the presence of malnutrition. It appears that micronutrient deficiencies contribute to immune dysfunction, infectious morbidity and disease progression. Limited interventive studies suggest that vitamin and mineral supplementation is beneficial to HIV-infected adults and children; however, current, regimens are not evidence-based and there are no randomised controlled trials in children. There are a number of African studies under way addressing these issues.
据推测，微量营养素在HIV疾病的发病机制中起作用。尽管数据稀少，但有证据表明，感染HIV的成人和儿童存在一系列微量营养素缺乏症，在疾病晚期和存在营养不良的情况下，缺乏症的严重程度会增加。微量营养素缺乏似乎会导致免疫功能障碍、感染性发病和疾病进展。有限的干预性研究表明，补充维生素和矿物质对感染HIV的成人和儿童有益；然而，目前的方案并非基于证据，且尚无针对儿童的随机对照试验。目前正在进行一些非洲研究以解决这些问题。
