Bonhomme F, Soulairac A
C R Seances Soc Biol Fil. 1975;169(1):69-72.
The addition of a second alpha-glyceryl to alpha-phenoxypropanediol strongly modifies the inhibitor actions on the synaptic transmission. These new di-ethers do not show solubility nor effect on the water superficial tension and simultaneously do not provoke any neurophysiological inhibitor effect. The ability of cellular penetration by lipidic solubility seems a necessary condition for pharmacological effect of alpha-glyceric ethers.
在α-苯氧基丙二醇上添加第二个α-甘油基会强烈改变其对突触传递的抑制作用。这些新的二醚既不表现出溶解性,也对水的表面张力没有影响,同时不会引发任何神经生理抑制效应。通过脂溶性实现细胞穿透的能力似乎是α-甘油醚产生药理作用的必要条件。