普拉克索治疗帕金森病。一项使用左旋多巴-多巴胺激动剂联合试验的短期研究。

Pramipexole in Parkinson's disease. A short-term study using the combined levodopa-dopamine agonist test.

作者信息

Fabbrini Giovanni, Barbanti Piero, Aurilia Cinzia, Pauletti Caterina, Meco Giuseppe

机构信息

Department of Neurosciences, University of Rome La Sapienza, Italy.

出版信息

Funct Neurol. 2002 Oct-Dec;17(4):199-201.

PMID:12675263

Abstract

The aim of our study was to investigate the efficacy of pramipexole in advanced parkinsonian patients by means of an acute stimulation test. We studied the motor effects of pramipexole in fluctuating parkinsonian patients by comparing the response to acute levodopa with the response to levodopa + pramipexole. The adjunct of pramipexole to levodopa increased the time spent on from 136 +/- 22.3 to 186 +/- 20.6 minutes (p<0.01), while it did not change the latency to on, the magnitude of the motor improvement, or the duration and severity of dyskinesias. The main effect of pramipexole in fluctuating parkinsonian patients is an increased duration of the on phase.

摘要

我们研究的目的是通过急性刺激试验来调查普拉克索在晚期帕金森病患者中的疗效。我们通过比较急性左旋多巴反应与左旋多巴+普拉克索反应，研究了普拉克索在症状波动型帕金森病患者中的运动效应。普拉克索与左旋多巴联用使“开”期时间从136±22.3分钟增加至186±20.6分钟（p<0.01），而对“开”期潜伏期、运动改善幅度、异动症持续时间及严重程度均无影响。普拉克索对症状波动型帕金森病患者的主要作用是延长“开”期时间。