Phillips S J, Ciborski M, Freed P S, Cascade P N, Jaron D
Ann Thorac Surg. 1976 Feb;21(2):134-7. doi: 10.1016/s0003-4975(10)64276-2.
A catheter-mounted polyurethane cusp was designed to act as a temporary prosthetic aortic valve in the ascending aorta. Acute aortic insufficiency was created in 15 dogs by transventricular tearing of the two aortic valve leaflets with a wire hook. Hemodynamic variables were measured during aortic insufficiency and with the prosthetic valve in place. Comparison of the values showed that the prosthesis functioned as a competent aortic valve. Aortic diastolic pressure increased by 62 +/- 42%, pulse pressure was lowered by 44 +/- 9%, and left ventricular end-diastolic pressure decreased by 45 +/- 18%. Neither cardiac output, coronary blood flow, nor peak systolic pressure was significantly altered. The observed hemodynamic improvement and the simplicity of the design and application suggest that the prosthetic aortic valve may be applicable in the temporary treatment of decompensated aortic insufficiency.
一种安装在导管上的聚氨酯瓣叶被设计用于在升主动脉中充当临时人工主动脉瓣。通过用钢丝钩经心室撕裂两个主动脉瓣叶，在15只狗身上造成急性主动脉瓣关闭不全。在主动脉瓣关闭不全期间以及植入人工瓣膜后测量血流动力学变量。数值比较表明，该假体起到了有效的主动脉瓣作用。主动脉舒张压升高62±42%，脉压降低44±9%，左心室舒张末期压力降低45±18%。心输出量、冠状动脉血流量和收缩压峰值均未发生显著改变。观察到的血流动力学改善以及设计和应用的简单性表明，人工主动脉瓣可能适用于失代偿性主动脉瓣关闭不全的临时治疗。
