孕妇脂肪肉瘤的管理
Management of liposarcoma occurring in pregnant women.
作者信息
Yamamoto Tetsuji, Marui Takashi, Akisue Toshihiro, Hitora Toshiaki, Kawamoto Teruya, Nagira Keiko, Nakatani Tetsuya, Yoshiya Shinichi, Kurosaka Masahiro
机构信息
Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
出版信息
Anticancer Res. 2003 Jan-Feb;23(1B):799-802.
BACKGROUND
The coexistence of pregnancy and liposarcoma is rare. Only 12 cases of pregnancy-associated liposarcoma have previously been reported in the English-language literature.
MATERIALS AND METHODS
We present two cases of liposarcoma occurring in pregnant patients: one myxoid liposarcoma in a 29-year-old woman at 29 weeks' gestation; another well-differentiated liposarcoma in a 44-year-old woman at 22 weeks' gestation.
RESULTS
The first patient's infant was delivered by cesarean section after the confirmation of pulmonary maturity of the fetus. The patient was subsequently treated with chemotherapy and radiotherapy. The second patient awaited delivery until 32 weeks' gestation with no treatment of the tumor because she had a low-grade sarcoma. After cesarean section, surgical treatment followed.
CONCLUSION
Treatment of sarcomas occurring during pregnancy is difficult. Both mother and fetus should be appropriately managed, depending on the trimester at the time of diagnosis and the histological type and grade of the tumor.
背景
妊娠与脂肪肉瘤并存的情况较为罕见。此前英文文献中仅报道过12例妊娠相关脂肪肉瘤病例。
材料与方法
我们呈现两例发生于妊娠患者的脂肪肉瘤病例：一例为一名29岁女性，孕29周时患黏液样脂肪肉瘤；另一例为一名44岁女性，孕22周时患高分化脂肪肉瘤。
结果
首例患者在确认胎儿肺成熟后行剖宫产分娩。该患者随后接受了化疗和放疗。第二例患者因患低级别肉瘤，在未对肿瘤进行治疗的情况下等待至孕32周分娩。剖宫产术后，接着进行了手术治疗。
结论
妊娠期间发生的肉瘤治疗困难。应根据诊断时的孕周以及肿瘤的组织学类型和分级，对母亲和胎儿进行适当处理。
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