Phupong Vorapong, Witoonpanich Pairoj, Snabboon Thiti, Tharavej Chadin, Ultchaswadi Pornthip
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Arch Gynecol Obstet. 2005 Mar;271(3):276-9. doi: 10.1007/s00404-004-0654-6. Epub 2004 Jun 18.
Pheochromocytoma is a rare disease of the chromaffin cells that secrete catecholamines. It may occur during pregnancy. Bilateral pheochromocytoma in pregnancy is even rarer.
A 26-year-old woman, gravida 2, para 0-0-1-0, 18 weeks' pregnancy, was initially seen with elevated blood pressure (170/100 mmHg) and mild headache. The cause of hypertension was conventionally investigated and bilateral pheochromocytoma was finally searched for and found. Bilateral adrenalectomy was undertaken at 23 weeks' gestation and Cesarean section was performed at 31 weeks' gestation due to intrauterine growth retardation (IUGR) and compromised fetal well-being. The maternal outcome was uneventful and the baby was physiologically complicated only by neonatal jaundice.
Pheochromocytoma should be searched for in the conventionally differential diagnosis in hypertension during pregnancy, especially in the young. Early diagnosis and proper management with medical treatment followed by surgical removal of the tumor usually result in good maternal and fetal outcomes.
嗜铬细胞瘤是一种由分泌儿茶酚胺的嗜铬细胞发生的罕见疾病。它可能在孕期发生。孕期双侧嗜铬细胞瘤更为罕见。
一名26岁女性,孕2产0-0-1-0,妊娠18周,初诊时血压升高(170/100 mmHg)且伴有轻度头痛。按常规对高血压病因进行了检查,最终排查并发现了双侧嗜铬细胞瘤。在妊娠23周时进行了双侧肾上腺切除术,由于胎儿宫内生长受限(IUGR)及胎儿健康状况不佳,在妊娠31周时进行了剖宫产。母亲结局平稳,婴儿仅在生理上出现了新生儿黄疸并发症。
在孕期高血压的常规鉴别诊断中应排查嗜铬细胞瘤,尤其是在年轻患者中。早期诊断并通过药物治疗进行妥善管理,随后手术切除肿瘤,通常会取得良好的母婴结局。