Desser T S, Rubin D L, Muller H, McIntire G L, Bacon E R, Hollister K R
Department of Radiology, VA Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA 94304, USA.
Acad Radiol. 1999 Feb;6(2):112-8. doi: 10.1016/s1076-6332(99)80490-5.
The authors assessed the efficacy of two gadolinium-based polymers used as lymphotrophic contrast media for computed tomography (CT) and magnetic resonance (MR) imaging.
Two gadolinium-based polymers, gadolinium diethylenetriaminepentaacetic acid (DTPA)-co-1,6-diaminohexane (NC 22181) and Gd-DTPA-co-alpha, omega-diamino-polyethylene glycol(1450) (NC-66368), were formulated at a concentration of 80 mmol/L gadolinium. Doses of 0.1, 0.25, 1.0, or 2.0 mL per paw were administered subcutaneously into the hindpaws of normal rabbits. Spin-echo T1-weighted MR imaging (1.5 T) of rabbit popliteal and iliac nodes was performed before and immediately, 10 minutes, 2-3 hours, and 24 hours after injection. CT was performed 2-3 hours after injection of the high doses only.
MR imaging revealed prompt enhancement of the popliteal nodes with both polymers at doses of 0.25 mL and above. For doses of 1.0 mL or less per paw, nodal percentage enhancement was maximal at 2 hours and then declined at 24 hours. At the highest doses, however, a reservoir of subcutaneous contrast material remained at the injection site and resulted in peak enhancement at 24 hours. At CT, popliteal node enhancement was faintly visible 2-3 hours after the administration of NC 22181. At lower doses, no enhancement was appreciable at CT.
At 80 mmol/L formulations, the two gadolinium-based polymers provide excellent popliteal nodal enhancement on MR images. In addition, high doses of one polymer (NC 22181) were sufficiently concentrated in popliteal nodes to be visible on CT scans. Thus, this agent may be useful for both CT and MR lymphography.
作者评估了两种用作淋巴趋向性造影剂的钆基聚合物在计算机断层扫描（CT）和磁共振（MR）成像中的效果。
两种钆基聚合物，钆二乙烯三胺五乙酸（DTPA）-共-1,6-二氨基己烷（NC 22181）和钆-DTPA-共-α,ω-二氨基聚乙二醇（1450）（NC-66368），配制成钆浓度为80 mmol/L的制剂。将每只爪子0.1、0.25、1.0或2.0 mL的剂量皮下注射到正常兔的后爪中。在注射前以及注射后即刻、10分钟、2 - 3小时和24小时对兔腘窝和髂淋巴结进行自旋回波T1加权MR成像（1.5 T）。仅在注射高剂量后2 - 3小时进行CT检查。
MR成像显示，两种聚合物在剂量为0.25 mL及以上时，腘窝淋巴结迅速增强。对于每只爪子1.0 mL或更低的剂量，淋巴结增强百分比在2小时时最大，然后在24小时时下降。然而，在最高剂量时，皮下造影剂在注射部位蓄积，导致在24小时时出现增强峰值。在CT检查中，注射NC 22181后2 - 3小时，腘窝淋巴结增强隐约可见。在较低剂量时，CT检查未见明显增强。
在80 mmol/L制剂中，两种钆基聚合物在MR图像上能使腘窝淋巴结得到良好增强。此外，高剂量的一种聚合物（NC 22181）在腘窝淋巴结中充分浓缩，在CT扫描中可见。因此，该制剂可能对CT和MR淋巴造影均有用。
