Cohen Hagit, Kaplan Zeev, Kotler Moshe, Mittelman Irena, Osher Yamima, Bersudsky Yuly
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Bipolar Disord. 2003 Apr;5(2):138-43. doi: 10.1034/j.1399-5618.2003.00027.x.
Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function.
We studied 39 euthymic bipolar patients and 39 controls, matched for age and sex. A high-resolution electrocardiogram was obtained during complete rest. Spectral analysis of R-R intervals was performed by the fast Fourier transform algorithm.
Euthymic bipolar patients at rest are characterized by markedly low HRV, independent of specific drug treatments.
While these results of autonomic stability in euthymic bipolar patients are counter-intuitive, the findings may be important in understanding pathophysiology of bipolar affective illness.
心率变异性（HRV）的功率谱分析最近已被证明是一种可靠的非侵入性测试，用于定量评估调节心血管自主功能的中枢交感迷走神经相互作用。
我们研究了39名心境正常的双相情感障碍患者和39名年龄及性别相匹配的对照组。在完全休息期间记录高分辨率心电图。采用快速傅里叶变换算法对R-R间期进行频谱分析。
心境正常的双相情感障碍患者在休息时的特点是HRV显著降低，且与特定药物治疗无关。
虽然心境正常的双相情感障碍患者自主神经稳定性的这些结果有悖直觉，但这些发现可能对理解双相情感障碍的病理生理学很重要。
