Trokovic Ras, Trokovic Nina, Hernesniemi Sanna, Pirvola Ulla, Vogt Weisenhorn Daniela M, Rossant Janet, McMahon Andrew P, Wurst Wolfgang, Partanen Juha
Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland.
EMBO J. 2003 Apr 15;22(8):1811-23. doi: 10.1093/emboj/cdg169.
Fibroblast growth factors (FGFs) are signaling molecules of the isthmic organizer, which regulates development of the midbrain and cerebellum. Tissue-specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi in the posterior midbrain and vermis of the cerebellum. Analyses of both midbrain-hindbrain and midbrain-specific Fgfr1 mutants suggest that after establishment of the isthmic organizer, FGFR1 is needed for continued response to the isthmic signals, and that it has direct functions on both sides of the organizer. In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border.
成纤维细胞生长因子（FGFs）是峡部组织者的信号分子，其调节中脑和小脑的发育。在小鼠胚胎的中脑和后脑的菱脑节1中，成纤维细胞生长因子受体（FGFR）基因之一Fgfr1的组织特异性失活导致中脑后部的下丘和小脑蚓部缺失。对中脑-后脑和中脑特异性Fgfr1突变体的分析表明，在峡部组织者建立后，FGFR1是持续响应峡部信号所必需的，并且它在组织者两侧都具有直接功能。此外，FGFR1似乎会改变对维持连贯的组织中心至关重要的细胞黏附特性。这可能是通过调节中脑-后脑边界处特定细胞黏附分子的表达来实现的。
