[角膜中的血管生成与淋巴管生成。发病机制、临床意义及治疗选择]
[Angiogenesis and lymphangiogenesis in the cornea. Pathogenesis, clinical implications and treatment options].
作者信息
Cursiefen C, Seitz B, Dana M R, Streilein J W
机构信息
Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen.
出版信息
Ophthalmologe. 2003 Apr;100(4):292-9. doi: 10.1007/s00347-003-0798-y.
BACKGROUND
Whereas the normal cornea is devoid of blood and lymphatic vessels,both can invade the cornea secondary to a variety of corneal diseases and after surgery. This not only reduces visual acuity, but also renders such a cornea high-risk, if subsequent corneal transplantation is performed.
METHODS
A PUBMED-based literature search was carried out.
RESULTS
Current knowledge on pathogenesis, clinical implications and treatment modalities for corneal neovascularization is discussed.
CONCLUSIONS
Novel anti-angiogenic and antilymphangiogenic therapeutic strategies should reduce blindness associated with corneal neovascularization and subsequent graft rejection.
背景
正常角膜无血管和淋巴管，但在多种角膜疾病及手术后，血管和淋巴管均可侵入角膜。这不仅会降低视力，而且如果后续进行角膜移植，会使这样的角膜处于高风险状态。
方法
基于PubMed进行文献检索。
结果
讨论了目前关于角膜新生血管形成的发病机制、临床意义及治疗方式的知识。
结论
新型抗血管生成和抗淋巴管生成治疗策略应能减少与角膜新生血管形成及后续移植排斥相关的失明情况。
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