Bushma M I, Zimatkin S M, Ambrushkevich IuG, Legon'kova L F, Karaedova L M, Bushma T V, Khomich T I, Sheĭbak V M
Grodno State Medical University, M. Gor'kogo Str., 80, Grodno, 230015 Belarus.
Eksp Klin Farmakol. 2003 Jan-Feb;66(1):60-3.
A new methodological approach capable of revealing factors responsible for the susceptibility of rat liver to ethanol hepatotoxicity has been developed. Using the correlation, dispersion, iteration, multifactor regression, and canonical analyses, a relation was established between the initial state of the liver antioxidant system and the character and degree of the subsequent ethanol-induced damage. In particular, it was found that intact animals with initially low level of reduced glutathione and retinols in the liver, as well as those with enzymopathy of cytosol HDNB-glutathione-8-transferase, are more susceptible to the ethanol liver damage.
一种能够揭示大鼠肝脏对乙醇肝毒性易感性相关因素的新方法已经开发出来。通过相关性、离散度、迭代、多因素回归和典型分析，建立了肝脏抗氧化系统的初始状态与随后乙醇诱导损伤的特征和程度之间的关系。特别是，发现肝脏中还原型谷胱甘肽和视黄醇初始水平较低的完整动物，以及那些具有胞质HDNB - 谷胱甘肽 - 8转移酶酶病的动物，对乙醇肝损伤更敏感。
