吸烟对过敏性鼻炎患者气道对5'-单磷酸腺苷反应性的影响。

Effect of cigarette smoking on airway responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.

作者信息

Prieto Luis, Gutiérrez Valentina, Uixera Sonia, Bertó J Manuel

机构信息

Sección de Alergología and Universidad de Valencia, Spain.

出版信息

Chest. 2003 Apr;123(4):993-7. doi: 10.1378/chest.123.4.993.

DOI:10.1378/chest.123.4.993

PMID:12684285

Abstract

STUDY OBJECTIVES

The objective of this study was to determine differences in airway responsiveness to adenosine 5'-monophosphate (AMP) between smokers and nonsmokers with allergic rhinitis.

METHODS

A total of 41 adults with allergic rhinitis (16 smokers and 25 nonsmokers) were challenged with increasing concentrations of methacholine and AMP. Airflow was assessed after each concentration, and the response to each bronchoconstrictor agent was measured by the provocative concentration required to produce a 20% fall in FEV(1) (PC(20)).

RESULTS

The geometric mean PC(20) AMP values were significantly lower in smokers than in nonsmokers: 72.4 mg/mL (95% confidence interval [CI], 33.9 to 154.9) vs 204.2 mg/mL (95% CI, 120.2 to 346.7) [p = 0.021]. The proportion of subjects with bronchoconstriction in response to AMP was higher in smokers (12 of 16 subjects) than in nonsmokers (7 of 25 subjects) [p = 0.005].

CONCLUSIONS

We conclude that smokers with allergic rhinitis have a greater AMP sensitivity than nonsmokers.

摘要

研究目的

本研究的目的是确定患有过敏性鼻炎的吸烟者和非吸烟者对5'-单磷酸腺苷（AMP）的气道反应性差异。

方法

共有41名患有过敏性鼻炎的成年人（16名吸烟者和25名非吸烟者）接受了递增浓度的乙酰甲胆碱和AMP激发试验。在每个浓度后评估气流情况，并通过使第一秒用力呼气容积（FEV(1)）下降20%所需的激发浓度（PC(20)）来测量对每种支气管收缩剂的反应。

结果

吸烟者的AMP几何平均PC(20)值显著低于非吸烟者：72.4毫克/毫升（95%置信区间[CI]，33.9至154.9）对比204.2毫克/毫升（95%CI，120.2至346.7）[p = 0.021]。对AMP有支气管收缩反应的受试者比例在吸烟者（16名受试者中的12名）中高于非吸烟者（25名受试者中的7名）[p = 0.005]。