Frasnelli Johannes, Lötsch Jörn, Hummel Thomas
Department of Otorhinolaryngology, University of Dresden Medical School, Germany.
J Clin Neurophysiol. 2003 Feb;20(1):80-6. doi: 10.1097/00004691-200302000-00011.
Few data are available on the relation of EEG-derived trigeminal event-related potentials (ERPs) to stimulus duration or stimulus concentration. Thus, the aim of this study was to analyze the relation between ERP components and both stimulus duration and stimulus concentration. Twenty healthy young subjects participated. Trigeminal ERPs were recorded after stimulation with CO(2). Five concentrations (45 to 65% volume per volume CO(2)) and five stimulus durations (100 to 300 msec) were used. Trigeminal ERPs were quantified in terms of amplitudes and latencies of its major peaks N(410) (termed N1) and P(622) (termed P3). The relation between stimulus duration, concentration, and amplitudes or latencies of trigeminal ERP components could be described as a model of power, following the formula p = b + k.I g1.D(g2). A linear relationship was found between stimulus concentration, amplitude N1, and amplitude P3, and between stimulus duration and amplitude P3 respectively. Furthermore, a linear relationship was seen between intensity ratings, and stimulus duration and concentration. These data confirm that the different ERP components encode different stimulus characteristics. Specifically, later components of the trigeminal ERP encode not only stimulus concentration but, other than earlier ERP components, also encode stimulus duration. Thus, they reflect the integration of stimuli over relatively long periods of time.
关于脑电图衍生的三叉神经事件相关电位（ERP）与刺激持续时间或刺激浓度之间的关系，目前可用的数据很少。因此，本研究的目的是分析ERP成分与刺激持续时间和刺激浓度之间的关系。20名健康的年轻受试者参与了研究。在用CO₂刺激后记录三叉神经ERP。使用了五种浓度（45%至65%体积/体积的CO₂）和五种刺激持续时间（100至300毫秒）。三叉神经ERP根据其主要峰值N(410)（称为N1）和P(622)（称为P3）的幅度和潜伏期进行量化。刺激持续时间、浓度与三叉神经ERP成分的幅度或潜伏期之间的关系可以用幂模型来描述，公式为p = b + k.I g1.D(g2)。分别在刺激浓度、幅度N1和幅度P3之间，以及刺激持续时间和幅度P3之间发现了线性关系。此外，在强度评级与刺激持续时间和浓度之间也观察到了线性关系。这些数据证实，不同的ERP成分编码不同的刺激特征。具体而言，三叉神经ERP的后期成分不仅编码刺激浓度，而且与早期ERP成分不同，还编码刺激持续时间。因此，它们反映了较长时间段内刺激的整合情况。
