[用于研究热带地区疟疾的队列和生物样本库]
[Cohorts and bio-libraries for studying malaria in tropical areas].
作者信息
Rogier C, Tall A, Faye J, Guillote M, Blanc C, Trape J-F, Spiegel A, Marrama L, Nabeth P, Fontenille D, Druilhe P, Puijalon O
机构信息
Institut Pasteur de Dakar, Dakar, Sénégal.
出版信息
Rev Epidemiol Sante Publique. 2003 Feb;51(1 Pt 2):175-82.
The relationship between Plasmodii transmission, infection, morbidity, genetic susceptibility and acquisition of natural immunity is studied among two cohorts in the Senegalese villages of Dielmo (300 inhabitants) and Ndiop (350 inhabitants) where malaria is holoendemic (about 200 P. falciparum infective bites/person/year) and mesoendemic (about 20 P. falciparum infective bites/person/year), respectively. The populations are under a daily active clinical survey. Blood samples are collected at least once per month. Plasma and red blood cells are stored in bio-libraries that allow longitudinal studies of the immune responses against plasmodial antigens and the investigation of the natural history of P. falciparum infections by molecular genotyping methods.
在塞内加尔的迪耶尔莫村（300名居民）和恩迪奥普村（350名居民）的两个队列中，研究了疟原虫传播、感染、发病率、遗传易感性和获得自然免疫力之间的关系。在迪耶尔莫村，疟疾为高度地方性流行（约200次恶性疟原虫感染性叮咬/人/年），而在恩迪奥普村为中度地方性流行（约20次恶性疟原虫感染性叮咬/人/年）。对这些人群进行每日主动临床调查。每月至少采集一次血样。血浆和红细胞储存在生物样本库中，这使得能够通过分子基因分型方法对针对疟原虫抗原的免疫反应进行纵向研究，并调查恶性疟原虫感染的自然史。
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