Hoenderop Joost G J, Nilius Bernd, Bindels René J M
Department of Cell Physiology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Pflugers Arch. 2003 Jun;446(3):304-8. doi: 10.1007/s00424-003-1045-8. Epub 2003 Mar 27.
The epithelial calcium channels TRPV5 and TRPV6 have been studied extensively in the epithelial tissues controlling Ca(2+) homeostasis and exhibit a range of distinctive properties that distinguish them from other transient receptor potential (TRP) channels. These two novel members of the superfamily of TRP channels were cloned from vitamin D-responsive epithelia: kidney, small intestine and placenta, and identified subsequently in tissues like pancreas, bone and prostate. This review addresses the unique properties of these highly Ca(2+)-selective channels and highlights their implications for the process of transepithelial Ca(2+) transport.
上皮钙通道TRPV5和TRPV6已在控制钙（Ca2+）稳态的上皮组织中得到广泛研究，它们具有一系列独特特性，使其有别于其他瞬时受体电位（TRP）通道。这两种TRP通道超家族的新成员是从对维生素D有反应的上皮组织（肾脏、小肠和胎盘）中克隆出来的，随后在胰腺、骨骼和前列腺等组织中也得到了确认。本综述阐述了这些高度钙（Ca2+）选择性通道的独特特性，并强调了它们在跨上皮钙（Ca2+）转运过程中的意义。
