Hoenderop Joost G J, Nilius Bernd, Bindels René J M
Department of Cell Physiology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre Nijmegen, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands.
Biochim Biophys Acta. 2002 Nov 4;1600(1-2):6-11. doi: 10.1016/s1570-9639(02)00438-7.
The epithelial Ca(2+) channels (ECaCs) are primarily expressed in Ca(2+) transporting epithelia and represent a new family of Ca(2+) channels that belong to the superfamily of transient receptor potential (TRP) channels. Two members, namely ECaC1 and ECaC2, have been identified from kidney and intestine, respectively. These channels are the prime target for hormonal control of active Ca(2+) flux from the urine space or intestinal lumen to the blood compartment. This review covers the distinctive properties of these highly Ca(2+)-selective channels and highlights the implications for our understanding of the process of transepithelial Ca(2+) transport.
上皮钙通道（ECaCs）主要表达于钙转运上皮细胞，代表了一个属于瞬时受体电位（TRP）通道超家族的新的钙通道家族。已分别从肾脏和肠道中鉴定出两个成员，即ECaC1和ECaC2。这些通道是激素控制活性钙从尿液空间或肠腔向血液腔转运的主要靶点。本综述涵盖了这些高度钙选择性通道的独特特性，并强调了其对我们理解跨上皮钙转运过程的意义。
