多巴胺能缺陷及氨磺必利在精神分裂症治疗中的作用。
Dopaminergic deficit and the role of amisulpride in the treatment of schizophrenia.
作者信息
Kasper Siegfried
机构信息
Department of General Psychiatry, University of Vienna, Vienna, Austria.
出版信息
Int Clin Psychopharmacol. 2002 Dec;17 Suppl 4:S19-26.
This review provides an overview of the evidence related to the role of dopamine deficiency in the pathogenesis of positive and negative schizophrenic symptoms and to the therapeutic use of amisulpride in this indication. It includes concepts of human neurobiology and neuropharmacology and their application to clinical medicine, as well as the presentation of the clinical evidence on the therapeutic efficacy and safety of amisulpride in schizophrenia, highlighting dosage issues.
本综述概述了与多巴胺缺乏在精神分裂症阳性和阴性症状发病机制中的作用以及氨磺必利在此适应症中的治疗应用相关的证据。它涵盖了人类神经生物学和神经药理学的概念及其在临床医学中的应用，还介绍了氨磺必利治疗精神分裂症的疗效和安全性的临床证据，重点强调了剂量问题。
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