Wikgren Jan, Ruusuvirta Timo, Korhonen Tapani
Department of Psychology, University of Jyväskylä, 40014, Jyväskylä, Finland.
Neurosci Lett. 2003 May 1;341(2):119-22. doi: 10.1016/s0304-3940(03)00180-0.
Behavioral responses and neural responses in the somatosensory cortex were recorded in nine rabbits during the unpaired and paired treatments of classical eyeblink conditioning with a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus. During the unpaired treatment, neither the behavioral nor neural responses to the CS were observed. During the paired treatment, behavioral conditioned response (CR), accompanied by neural activity, was developed. In well-trained animals occasional failures to elicit the CR were accompanied by an absence of neural responses. Nevertheless, the CS modified the behavioral unconditioned response in paired trials, implying that the CR-failures could not reflect the inability of the CS to modulate the pathways triggering the behavior constituting the CR. Thus, a close link between CR elicitation and somatosensory cortical neural response was established. Our finding suggests that this neural activity to a tone CS during classical eyeblink conditioning reflects an efferent copy of the procedural memory trace.
在九只兔子身上记录了体感皮层的行为反应和神经反应，这些兔子在经典眨眼条件反射的非配对和配对处理过程中，使用音调条件刺激（CS）和气吹非条件刺激。在非配对处理期间，未观察到对CS的行为或神经反应。在配对处理期间，伴随着神经活动，出现了行为条件反应（CR）。在训练良好的动物中，偶尔无法引发CR伴随着神经反应的缺失。然而，CS在配对试验中改变了行为非条件反应，这意味着CR失败不能反映CS无法调节触发构成CR行为的通路。因此，建立了CR引发与体感皮层神经反应之间的紧密联系。我们的发现表明，在经典眨眼条件反射期间，这种对音调CS的神经活动反映了程序记忆痕迹的传出副本。
