Ohtsuka Eiji, Kawai Sanae, Nojima Hiroshi, Andoh Tsugunobu, Kamimura Kiyoshi, Kuraishi Yasushi
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan.
J Pharmacol Sci. 2003 Mar;91(3):263-6. doi: 10.1254/jphs.91.263.
We examined whether azelastine would inhibit itch-associated responses of mice to mosquito allergy. Repeated injections of mosquito salivary gland extract increased scratching and sensory nerve activity. Azelastine inhibited the increased scratching and nerve activity, while terfenadine was without effects. Dexamethasone did not affect the increased scratching. Azelastine suppressed high K(+)-induced increase in intracellular free Ca(2+) in primary cultures of mouse sensory neurons. Direct inhibition by azelastine of sensory neurons may be at least involved in the anti-pruritic effect of azelastine. Histamine, substance P, and leukotriene B(4) may not play a key role in the itching of mosquito allergy.
我们研究了氮卓斯汀是否会抑制小鼠对蚊虫过敏的瘙痒相关反应。反复注射蚊虫唾液腺提取物会增加抓挠行为和感觉神经活动。氮卓斯汀抑制了增加的抓挠行为和神经活动，而特非那定则无此作用。地塞米松不影响增加的抓挠行为。氮卓斯汀抑制了原代培养的小鼠感觉神经元中高钾诱导的细胞内游离钙增加。氮卓斯汀对感觉神经元的直接抑制作用可能至少参与了其止痒作用。组胺、P物质和白三烯B4可能在蚊虫过敏瘙痒中不起关键作用。
