Studzinski George P, Harrison Jonathan S
Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
Leuk Lymphoma. 2003 Feb;44(2):235-40. doi: 10.1080/1042819021000030009.
Cyclin-dependent kinase 5 (Cdk5) and its activator p35Nck5a are an odd but interesting couple. Recent work has established that in spite of their names, Cdk5 is clearly not cyclin-dependent, while p35Nck5a is not exclusively neuronal. Indeed, p35Nck5a and/or Cdk5 activity has been demonstrated to be present in human and rat promyelocytic cell lines, and in normal human monocytes. Further, monocytes from mice in which p35Nck5a gene was deleted do not express non-specific esterase, an enzyme present in normal monocytes, while transfection of Cdk5 together with p35Nck5a into myeloblastic cells leads to the expression of this marker of the monocytic phenotype. Thus, the Cdk5/p35Nck5a complex appears to play an important role in monocytic differentiation.
细胞周期蛋白依赖性激酶5（Cdk5）及其激活剂p35Nck5a是一对奇特却有趣的组合。近期研究表明，尽管它们有这样的名字，但Cdk5显然不依赖细胞周期蛋白，而p35Nck5a也并非仅存在于神经元中。事实上，已证实在人及大鼠早幼粒细胞系以及正常人单核细胞中存在p35Nck5a和/或Cdk5活性。此外，p35Nck5a基因缺失的小鼠的单核细胞不表达非特异性酯酶（一种正常单核细胞中存在的酶），而将Cdk5与p35Nck5a共同转染到成髓细胞中会导致单核细胞表型标志物的表达。因此，Cdk5/p35Nck5a复合物似乎在单核细胞分化中发挥重要作用。
