Tao Tao, Alemany Lawrence B, Parry Ronald J
Department of Chemistry MS65, Rice University, 6100 Main St., Houston, Texas 77005, USA.
Org Lett. 2003 Apr 17;5(8):1213-5. doi: 10.1021/ol0340989.
[reaction: see text] The incorporation of [(15)N, (18)O]-isobutylhydroxylamine into the antibiotic valanimycin by Streptomyces viridifaciens has been shown to proceed with loss of the (18)O label, thereby demonstrating that the azoxy oxygen atom of valanimycin is not derived from the oxygen atom of isobutylhydroxylamine.
[反应：见正文] 已表明绿色产色链霉菌将[(15)N, (18)O]-异丁基羟胺掺入抗生素瓦拉霉素的过程中，(18)O标记会丢失，从而证明瓦拉霉素的偶氮氧原子并非来源于异丁基羟胺的氧原子。
