（+）-盘尼西丁的形式合成。
Formal synthesis of (+)-discodermolide.
作者信息
Francavilla Charles, Chen Weichun, Kinder Frederick R
机构信息
Novartis Pharmaceuticals Corporation, Oncology Research, 556 Morris Avenue, Summit, New Jersey 07901, USA.
出版信息
Org Lett. 2003 Apr 17;5(8):1233-6. doi: 10.1021/ol034186t.
PMID:12688727
Abstract
[structure: see text] Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C(9-18) and C(19-24) fragments via a metal-chelated aldol coupling reaction.
摘要
[结构：见正文] 在此，我们报道了以市售罗氏酯为原料，经21步反应（最长线性序列）实现（+）-片螺素的形式全合成。该合成的特点是通过金属螯合羟醛缩合反应组装C（9-18）和C（19-24）片段。
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