Duarte Natalia L, Colagiuri Stephen, Palu Taniela, Wang Xing Li, Wilcken David E L
Cardiovascular Genetics Laboratory, Department of Medicine, Prince of Wales Hospital, University of New South Wales, Sydney, Australia.
Obes Res. 2003 Apr;11(4):512-7. doi: 10.1038/oby.2003.72.
We compared the current prevalence of increased BMI and type 2 diabetes in a representative group of Tongan subjects with measurements made in 1973, and we determined the distribution and possible interrelations with the UCP2 insertion/deletion (ins/del) polymorphism of these variables. We documented the BMI, glucose tolerance, and standard lipid variables in 1012 Tongan subjects (429 men and 583 women, ages 15 to 85 years) during 1998 and 2000 and compared the BMI findings with those of the 1973 survey. We also genotyped for the UCP2 ins/del polymorphism, assessed its association with obesity and type 2 diabetes, and compared its prevalence with those reported for other ethnic populations. The mean BMI +/- SD was greatly increased in both men (30.2 +/- 5.4 kg/m(2)) and women (33.8 +/- 6.2 kg/m(2)), representing increases since 1973 of 11.9% and 19.4%, respectively. The genotype frequencies were 97% for the del/del genotype and 3% for the ins/del genotype; we found no ins/ins homozygotes. This distribution is strikingly different from those reported for white, South Indian, Pima Native-American, and Asian populations (49 to 77% for del/del genotype). We conclude that there is a marked prevalence of obesity in Tonga, a prevalence that has increased since 1973. We also conclude that there is a unique, near-uniform distribution of the UCP2 45-bp ins/del polymorphism in Tongans. This may be the result of a founder effect and may be relevant to the prevalence of obesity and type 2 diabetes in Tonga.
我们将一组具有代表性的汤加受试者当前的体重指数（BMI）升高和2型糖尿病患病率与1973年的测量结果进行了比较，并确定了这些变量与解偶联蛋白2（UCP2）插入/缺失（ins/del）多态性之间的分布及可能的相互关系。我们记录了1998年至2000年间1012名汤加受试者（429名男性和583名女性，年龄在15至85岁之间）的BMI、糖耐量和标准血脂变量，并将BMI结果与1973年的调查结果进行了比较。我们还对UCP2 ins/del多态性进行了基因分型，评估了其与肥胖症和2型糖尿病的关联，并将其患病率与其他种族人群的报告患病率进行了比较。男性（30.2±5.4kg/m²）和女性（33.8±6.2kg/m²）的平均BMI±标准差均大幅升高，分别代表自1973年以来增加了11.9%和19.4%。del/del基因型的基因频率为97%，ins/del基因型的基因频率为3%；我们未发现ins/ins纯合子。这种分布与白人、南印度人、皮马美洲原住民和亚洲人群的报告分布（del/del基因型为49%至77%）显著不同。我们得出结论，汤加存在明显的肥胖症患病率，且自1973年以来患病率有所上升。我们还得出结论，汤加人UCP2 45bp ins/del多态性存在独特的、近乎一致的分布。这可能是奠基者效应的结果，可能与汤加肥胖症和2型糖尿病的患病率有关。
