Sun Joseph C, Bevan Michael J
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Science. 2003 Apr 11;300(5617):339-42. doi: 10.1126/science.1083317.
The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
人们认为，CD8+细胞毒性T细胞对病原体的反应是独立于CD4+辅助性T细胞的，因为感染因子自身会提供炎症信号。缺乏CD4+ T细胞的小鼠对单核细胞增生李斯特菌产生的初始CD8反应与野生型小鼠相当，并能迅速清除感染。然而，在前者这些动物中，针对再次攻击的保护性记忆会逐渐丧失。正常小鼠的记忆性CD8+ T细胞能够快速做出反应，但在没有CD4辅助的情况下产生的记忆性CD8+ T细胞在应对再次接触抗原时的反应能力存在缺陷。这些结果凸显了CD4辅助在促进保护性CD8记忆形成方面此前未被描述的作用。
