Ozawa Shogo
Division of Pharmacology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501.
Rinsho Byori. 2003 Feb;51(2):168-73.
Wide inter-individual difference has been documented for various drug metabolizing enzymes(DMEs) and drug transporters. Some of the single nucleotide polymorphisms(SNPs) existing in the genes encoding DMEs and drug transporters have been associated with the deficiency of DMEs and the transporters. In the case of therapeutic drugs that undergo metabolism by a single DME, serious adverse effect might occur for patients who are devoid of the DME. Function of a number of DMEs and transporters are likely to affect drug effectiveness of three anti-cancer agents, irinotecan, taxol and 5-fluorouracil. Genetic polymorphisms of the genes related to the effectiveness of these drugs are discussed from the aspect of effects of the genetic polymorphisms on their metabolism and disposition.
各种药物代谢酶（DMEs）和药物转运体存在广泛的个体间差异。编码DMEs和药物转运体的基因中存在的一些单核苷酸多态性（SNPs）与DMEs和转运体的缺乏有关。对于由单一DME进行代谢的治疗药物，缺乏该DME的患者可能会出现严重的不良反应。许多DMEs和转运体的功能可能会影响三种抗癌药物伊立替康、紫杉醇和5-氟尿嘧啶的药物疗效。从基因多态性对这些药物代谢和处置的影响方面，讨论了与这些药物疗效相关基因的遗传多态性。
