Familial cardiomyopathies: significant causes of heart failure.

Familial dilated cardiomyopathies (FDCMs) account for about one third of idiopathic dilated cardiomyopathies, yet clinicians under-appreciate their prevalence. Among the inherited cardiomyopathies, FDCMs account for the greatest burden of heart failure and its associated morbidities. This paper summarizes significant molecular-genetic data, and discusses clinical manifestations of the major inherited cardiomyopathies, and the importance of clinical and genetic screening. Suggestions are provided as to how to proceed with screening. The purpose of this paper is to update clinicians about this rapidly growing scientific field, and to encourage application of current evidence to their practices.