Toft A D, Irvine W J, Campbell R W
Clin Endocrinol (Oxf). 1976 Mar;5(2):195-8. doi: 10.1111/j.1365-2265.1976.tb02833.x.
The effect of the beta-blocker, propranolol (40 mg 6-hourly orally) has been studied on the tachycardia of six patients with untreated thyrotoxicosis. Heart rate was monitored continuously using a light portable ECG recorder which allowed the patients to undertake normal activities during the recording periods. The most marked reduction in heart rate was evident at 24 h after starting propranolol treatment. In three of the patients there was only a minor further fall in heart rate despite continued propranolol administration, but in the remaining patients the reduction in heart rate with each successive day of treatment was more marked. These results suggest that if propranolol were to be used alone in the preparation of patients before partial thyroidectomy for thyrotoxicosis, a dose of 40 mg 6-hourly for 3-4 days might be sufficient.
已对6例未经治疗的甲状腺毒症患者，研究了β受体阻滞剂普萘洛尔（口服，40毫克，每6小时1次）对心动过速的影响。使用轻便型心电图记录仪连续监测心率，该记录仪使患者在记录期间能够进行正常活动。开始普萘洛尔治疗后24小时，心率下降最为明显。3例患者尽管继续服用普萘洛尔，但心率仅略有进一步下降，而其余患者在治疗的每一天，心率下降更为明显。这些结果表明，如果在甲状腺毒症患者行甲状腺部分切除术之前单独使用普萘洛尔进行准备，每6小时服用40毫克，持续3 - 4天可能就足够了。
