Postovsky Sergey, Lightman Abraham, Aminpour Dina, Elhasid Ronit, Peretz Monique, Arush Myriam Weyl Ben
Department of Pediatric Hemato-Oncology, Sperm bank, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Med Pediatr Oncol. 2003 Jun;40(6):355-9. doi: 10.1002/mpo.10294.
Referring male patients (pts) for pretreatment sperm cryopreservation (SCP) is a routine practice in adult oncology. Our aim was to evaluate the semen quality and feasibility of sperm cryopreservation in male adolescents diagnosed with cancer prior to the commencement of treatment.
All consecutive adolescents from 14 to 19 years of age with newly diagnosed cancer were referred to this study. The following parameters of semen analysis were investigated: (1) volume of collected sample (N >or= 2.0 ml); (2) total sperm concentration (N >or= 20 x 10(6)/ml); (3) percentage of motile spermatozoa (N >or= 50%). The results were compared with normal values characteristic of healthy young men.
Sixty-two attempts to collect sperm were made by the 27 adolescents. Of the 40/62 (64.5%) attempts, which resulted in a normal sperm count in each sample, only nine (22.5%) demonstrated normal sperm motility. Only 9/62 (14.5%) attempts resulted in normal sperm motility. Nineteen of 62 (30.6%) attempts produced a normal volume of ejaculate, while three pts were unable to produce any sperm. Only 4/62 (6.5%) attempts produced semen that could be considered normal in all the parameters.
Only a minority of adolescents newly diagnosed with cancer is able to produce sperm that can be considered normal, compared with healthy young men. Despite this, SCP should be offered and is a technically feasible procedure for these patients in light of the recent advances in assisted reproductive technologies. Further studies are required to develop treatment protocols for this group of pts to lessen damage to fertility function.
对于成年肿瘤患者，在进行预处理时进行精子冷冻保存（SCP）是一种常规做法。我们的目的是评估在治疗开始前被诊断患有癌症的男性青少年的精液质量以及精子冷冻保存的可行性。
所有年龄在14至19岁、新诊断为癌症的连续青少年均被纳入本研究。对精液分析的以下参数进行了调查：（1）采集样本的体积（N≥2.0毫升）；（2）精子总浓度（N≥20×10⁶/毫升）；（3）活动精子百分比（N≥50%）。将结果与健康年轻男性的正常值进行比较。
27名青少年共进行了62次精子采集尝试。在40/62（64.5%）次每次样本精子计数正常的尝试中，只有9次（22.5%）显示精子活力正常。只有9/62（14.5%）次尝试导致精子活力正常。62次尝试中有19次（30.6%）产生了正常体积的射精，而有3名患者未能产生任何精子。只有4/62（6.5%）次尝试产生的精液在所有参数上都可被视为正常。
与健康年轻男性相比，新诊断患有癌症的青少年中只有少数能够产生可被视为正常的精子。尽管如此，鉴于辅助生殖技术的最新进展，仍应为这些患者提供精子冷冻保存，且这在技术上是可行的。需要进一步研究为这组患者制定治疗方案，以减少对生育功能的损害。
