Schmiegelow M, Hansen M M, Nielsen N C
Medicinsk haematologisk afdeling L, Rigshospitalet, København.
Ugeskr Laeger. 1995 Mar 13;157(11):1501-4.
Each year approximately 70 males are diagnosed with Hodgkin's disease (HD) in Denmark. Most of these are less than 50 years of age. Since chemotherapy and radiotherapy may induce infertility in about 80% of patients, it has become routine to offer cryopreservation of semen prior to initiation of treatment. In 41 men aged 17-42 years at diagnosis we evaluated the quality of semen (according to the WHO criteria) prior to cryopreservation and after thawing. The median sperm concentration at the time of diagnosis was 33 x 10(6)/ml (range: 0.3-458 x 10(6)/ml) and positively correlated to age (rs = 0.36 p = 0.02) and to the histopathological classification (highest for patients with nodular sclerosis (p = 0.04) but not to semen volume, stage or presence of B-symptoms. The percentage of motile spermatozoa (range: 0-90%, median value 72%) was correlated to the sperm concentration; but not to any of the other parameters studied. Prior to freezing, 19 of 41 patients had normal semen quality according to the WHO criteria, whereas following thawing this was the case for only 14 semen samples. Ten of 23 patients with nodular sclerosis HD had normal semen quality (according to the WHO criteria) after thawing whereas this was the case for only 2 of 15 patients with mixed cellularity HD (p = 0.05). Cryopreservation of semen may secure the possibility of fathering children for patients with HD following therapy, and is to be recommended.
在丹麦，每年约有70名男性被诊断为霍奇金淋巴瘤（HD）。其中大多数年龄小于50岁。由于化疗和放疗可能导致约80%的患者不育，因此在开始治疗前进行精液冷冻保存已成为常规操作。我们评估了41名确诊时年龄在17 - 42岁的男性在冷冻保存前和解冻后的精液质量（根据世界卫生组织标准）。诊断时精子浓度中位数为33×10⁶/ml（范围：0.3 - 458×10⁶/ml），与年龄呈正相关（rs = 0.36，p = 0.02），与组织病理学分类相关（结节硬化型患者最高，p = 0.04），但与精液量、分期或B症状的存在无关。活动精子百分比（范围：0 - 90%，中位数72%）与精子浓度相关，但与其他研究参数均无关。冷冻前，41名患者中有19名精液质量根据世界卫生组织标准正常，而解冻后只有14份精液样本如此。23名结节硬化型HD患者中有10名解冻后精液质量正常（根据世界卫生组织标准），而15名混合细胞型HD患者中只有2名如此（p = 0.05）。精液冷冻保存可为HD患者治疗后生育子女提供保障，值得推荐。
