Suka Machi, Kiyota Ayano, Yoshida Katsumi
Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki-city.
Ryumachi. 2003 Feb;43(1):29-38.
To develop disease burden score concerning bone and joint diseases by evaluating the burdens of rheumatoid arthritis (RA) and osteoarthritis (OA) based on two quantitative measures of quality of life (QOL).
In a questionnaire, the qualified doctors of Japan Rheumatism Foundation were asked to evaluate patients' QOL, including 6 items of physical functions, 7 items of daily living activities and 3 items of social activities, for three severity levels defined by treatment status. The burdens of RA and OA were determined based on two quantitative measures of QOL, that is, 'principal component score' and '0-0.5-1 score'.
In the two-way ANOVA of severity level and doctor's specialism, two quantitative measures of QOL showed significant differences by severity level, having approximately the same F-statistics each other. The burden of RA was 1.4-times (for 'principal component score') and 1.6-times (for '0-0.5-1 score') as great as that of OA. The differences in burden between RA and OA were observed especially in daily living activities and social activities.
Our methodology may be applicable to examining differences in burden between bone and joint diseases.
通过基于两种生活质量（QOL）定量测量方法评估类风湿性关节炎（RA）和骨关节炎（OA）的负担，制定有关骨与关节疾病的疾病负担评分。
在一份调查问卷中，日本风湿病基金会的合格医生被要求针对根据治疗状态定义的三个严重程度级别，评估患者的生活质量，包括6项身体功能、7项日常生活活动和3项社会活动。RA和OA的负担是基于生活质量的两种定量测量方法确定的，即“主成分得分”和“0 - 0.5 - 1得分”。
在严重程度级别和医生专业的双向方差分析中，生活质量的两种定量测量方法在严重程度级别上显示出显著差异，彼此的F统计量大致相同。RA的负担是OA的1.4倍（对于“主成分得分”）和1.6倍（对于“0 - 0.5 - 1得分”）。RA和OA之间的负担差异尤其在日常生活活动和社会活动中观察到。
我们的方法可能适用于检查骨与关节疾病之间的负担差异。
