[抗Hu抗原阳性患者的副肿瘤性神经综合征与小细胞肺癌]

[Paraneoplastic neurologic syndrome and small-cell lung cancer in a patient positive for anti-Hu antigen].

作者信息

Koyama Yoshiko, Miyashita Kouichi, Anzai Masaki, Kadowaki Maiko, Fujita Masakuni, Mizuno Shirou, Totani Yoshitaka, Demura Yoshiki, Ameshima Shingo, Ishizaki Takeshi, Miyamori Isamu

机构信息

Department of Internal Medicine, Fukui Medical University, 23-3, Shimo-Aizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193.

出版信息

Nihon Kokyuki Gakkai Zasshi. 2003 Jan;41(1):35-8.

PMID:12693003

Abstract

We encountered a case of small-cell lung cancer with paraneoplastic neurologic syndrome in a 68-year old man. Progressive dysesthesia had developed in his hands and legs over a period of 4 months. Chest radiography and chest CT scanning on admission showed a mass in the hilum of the left lung. Anti-Hu antibody was found in his serum and the subsequent histopathological diagnosis by TBLB was small cell lung cancer. The patient underwent complete remission, in terms of tumor size, as a result of concurrent chemoradiotherapy (cisplatin, etoposid) and the dysesthesia in his legs was alleviated.

摘要

我们遇到一例68岁男性小细胞肺癌伴副肿瘤性神经综合征。在4个月的时间里，他的手和腿部逐渐出现感觉异常。入院时胸部X线和胸部CT扫描显示左肺门有一个肿块。在他的血清中发现了抗Hu抗体，随后经支气管镜肺活检的组织病理学诊断为小细胞肺癌。由于同步放化疗（顺铂、依托泊苷），患者肿瘤大小实现完全缓解，腿部的感觉异常也得到缓解。