Koyama Yoshiko, Miyashita Kouichi, Anzai Masaki, Kadowaki Maiko, Fujita Masakuni, Mizuno Shirou, Totani Yoshitaka, Demura Yoshiki, Ameshima Shingo, Ishizaki Takeshi, Miyamori Isamu
Department of Internal Medicine, Fukui Medical University, 23-3, Shimo-Aizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193.
Nihon Kokyuki Gakkai Zasshi. 2003 Jan;41(1):35-8.
We encountered a case of small-cell lung cancer with paraneoplastic neurologic syndrome in a 68-year old man. Progressive dysesthesia had developed in his hands and legs over a period of 4 months. Chest radiography and chest CT scanning on admission showed a mass in the hilum of the left lung. Anti-Hu antibody was found in his serum and the subsequent histopathological diagnosis by TBLB was small cell lung cancer. The patient underwent complete remission, in terms of tumor size, as a result of concurrent chemoradiotherapy (cisplatin, etoposid) and the dysesthesia in his legs was alleviated.
我们遇到一例68岁男性小细胞肺癌伴副肿瘤性神经综合征。在4个月的时间里,他的手和腿部逐渐出现感觉异常。入院时胸部X线和胸部CT扫描显示左肺门有一个肿块。在他的血清中发现了抗Hu抗体,随后经支气管镜肺活检的组织病理学诊断为小细胞肺癌。由于同步放化疗(顺铂、依托泊苷),患者肿瘤大小实现完全缓解,腿部的感觉异常也得到缓解。