Noorda E M, Vrouenraets B C, Nieweg O E, Kroon B B R
Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, afd. Chirurgische Oncologie, Plesmanlaan 121, 1066 CX Amsterdam.
Ned Tijdschr Geneeskd. 2003 Mar 22;147(12):529-33.
In 3 patients over 75 years of age with a malignancy, limb salvage was achieved through the application of isolated limb perfusion with melphalan with or without tumour necrosis factor alpha: an 82-year-old woman with extensive locoregional melanoma metastases on her lower leg, a 78-year-old woman with a large, ulcerating recurrence of melanoma on her lower leg and an 83-year-old woman with recurrent sarcoma of the lower arm. There were no complications and the women recovered well. Isolated limb perfusion can be effectively and safely used in older patients with irresectable tumours of the extremities, offering them limb salvage for the remainder of their lives.
在3例75岁以上患有恶性肿瘤的患者中，通过应用美法仑单独肢体灌注（伴或不伴肿瘤坏死因子α）实现了保肢：一名82岁女性小腿部有广泛的局部区域黑色素瘤转移，一名78岁女性小腿部有黑色素瘤的巨大溃疡性复发，一名83岁女性有下臂复发性肉瘤。没有出现并发症，这些女性恢复良好。单独肢体灌注可有效且安全地用于患有不可切除的四肢肿瘤的老年患者，为他们提供余生的肢体保全。
