de Vries P J, Visser L G, Vetter H C M, Muller H P, Polderman A M
Afd. Interne Geneeskunde, onderafd. Infectieziekten, Tropische Geneeskunde en Aids, Academisch Medisch Centrum/Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam.
Ned Tijdschr Geneeskd. 2003 Mar 22;147(12):566-9.
In two women, aged 59 and 31 years, who suffered from an itching cutaneous nodule, subcutaneous dirofilariasis was diagnosed. The disease is characterised by recurrent migrating subcutaneous nodules and swellings. Both patients recently visited the South of France. Laboratory examination revealed a moderate eosinophilia. In both patients, filaria antibodies were demonstrated during the course of the disease and a nodule was eventually resected. Parasitological examination revealed Dirofilaria repens. After this the swellings did not recur. Dirofilariasis is a zoonosis common in dogs and cats, and is transmitted by mosquitoes. In humans, the most common clinical manifestation is a migrating subcutaneous nodule in the case of D. repens, and a pulmonary infiltrate (coin lesion on radiographs) in the case of Dirofilaria immitis. Filarial serology is often positive. The diagnosis is confirmed by parasitological examination of the excised nodule. Dirofilariasis is usually innocuous; it disappears after the worm has died but can cause patients to worry.
在两名分别为59岁和31岁的女性患者中,她们患有瘙痒性皮肤结节,被诊断为皮下恶丝虫病。该病的特征是反复出现迁移性皮下结节和肿胀。两名患者近期都去过法国南部。实验室检查显示有中度嗜酸性粒细胞增多。在两名患者疾病过程中均检测到丝虫抗体,最终切除了一个结节。寄生虫学检查发现了匐行恶丝虫。此后肿胀未再复发。恶丝虫病是一种在犬猫中常见的人畜共患病,由蚊子传播。在人类中,匐行恶丝虫感染最常见的临床表现是迁移性皮下结节,而犬恶丝虫感染则表现为肺部浸润(X线片上的钱币状病灶)。丝虫血清学检查通常呈阳性。通过对切除结节的寄生虫学检查来确诊。恶丝虫病通常无害;蠕虫死后该病会自行消失,但可能会让患者担忧。