乙型和丙型肝炎病毒——医护人员中的流行情况与预防
Hepatitis B and C virus--prevalence and prevention in health care workers.
作者信息
Duseja A, Arora L, Masih B, Singh H, Gupta A, Behera D, Chawla Y K, Dhiman R K
机构信息
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh.
出版信息
Trop Gastroenterol. 2002 Jul-Sep;23(3):125-6.
BACKGROUND
Hepatitis B and C viruses are important causes of liver related morbidity and mortality. We aimed at determining the presence of hepatitis B and C virus infections in the health care workers (HCWs) and their compliance for the HBV vaccination.
METHODS
Three thousand five hundred and fifty six health care workers were screened for HBsAg and 115 for anti-HCV by ELISA. HBsAg negative individual were offered HBV vaccination and record of their compliance was kept. Anti-HBs titers were determined one month after 2nd or 3rd dose of vaccine in 273 subjects.
RESULTS
Out of 3556 health care workers, 61 (1.7%) were found to be positive for HBsAg. One out of 115 HCWs (0.87%) was found to be positive for anti-HCV. Fifteen percent of HCWs received only one dose, 26% received two doses 59% received three doses and 2.5% also received the booster dose of the HBV vaccine. All those tested had anti-HBs titers more than 10 mUI/ml.
CONCLUSION
In HCWs, HBsAg and anti-HCV prevalence was found to be 1.7% and 0.87% respectively. HCWs in our hospital, despite the awareness on HBV and HCV infection are noncompliant for HBV vaccination.
背景
乙型肝炎病毒和丙型肝炎病毒是导致肝脏相关发病和死亡的重要原因。我们旨在确定医护人员中乙型肝炎病毒和丙型肝炎病毒感染的存在情况以及他们对乙肝疫苗接种的依从性。
方法
采用酶联免疫吸附测定法（ELISA）对3556名医护人员进行乙肝表面抗原（HBsAg）筛查，对115名医护人员进行抗丙型肝炎病毒（抗-HCV）筛查。对HBsAg阴性的个体提供乙肝疫苗接种，并记录他们的依从情况。在273名受试者接种第二剂或第三剂疫苗一个月后测定抗-HBs滴度。
结果
在3556名医护人员中，发现61人（1.7%）HBsAg呈阳性。在115名医护人员中，有1人（0.87%）抗-HCV呈阳性。15%的医护人员仅接种了一剂乙肝疫苗，26%接种了两剂，59%接种了三剂，2.5%还接种了乙肝疫苗的加强剂。所有检测者的抗-HBs滴度均超过10 mUI/ml。
结论
在医护人员中，HBsAg和抗-HCV的患病率分别为1.7%和0.87%。我院的医护人员尽管对乙肝和丙肝感染有认识，但对乙肝疫苗接种仍不依从。
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