Knapp E, Hammerle P, Auckenthaler S, Raas E, Gmeiner R
Dtsch Med Wochenschr. 1976 Jun 4;101(23):894-7. doi: 10.1055/s-0028-1104137.
Nitroprusside was infused intravenously (20, 40, 80 and 200 mug/min) in nine patients with pulmonary hypertension due to mitral stenosis (group I), nine with precapillary pulmonary hypertension associated with primary lung disease (group II) and nine with normal pulmonary-arterial pressures (group III). The mean pulmonary-arterial pressure was markedly reduced at a rate of 20 mug/min in group I and II, while higher doses were necessary in group III to produce a similar effect. Mean arterial pressure was decreased in all three groups and was dose-related. Heart rate rose, stroke volume fell during nitroprusside administration, while cardiac output remained unchanged. Pulmonary vascular resistance was reduced on 20 mug/min in group I, but only on 200 mug/min or more in group II, and unchanged at all dosages in group III. Peripheral vascular resistance declined in all three groups on nitroprusside infusion, which is apparently of value in the short-term lowering of pulmonary hypertension.
对9例二尖瓣狭窄所致肺动脉高压患者（I组）、9例与原发性肺部疾病相关的毛细血管前性肺动脉高压患者（II组）和9例肺动脉压正常患者（III组）静脉输注硝普钠（速率分别为20、40、80和200μg/min）。I组和II组中，平均肺动脉压在20μg/min的输注速率下显著降低，而III组则需要更高剂量才能产生类似效果。三组患者的平均动脉压均下降，且与剂量相关。硝普钠给药期间心率上升，每搏量下降，而心输出量保持不变。I组中20μg/min的输注速率可降低肺血管阻力，但II组仅在200μg/min或更高输注速率下肺血管阻力才降低，III组在所有剂量下肺血管阻力均无变化。输注硝普钠后，三组患者的外周血管阻力均下降，这显然对短期内降低肺动脉高压有价值。
