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Identification of a novel HLA-DRB1 allele: DRB1*1353.

作者信息

Longhi E, Frison S, Poli F, Gaboardi D, Ferrioli G, Scalamogna M

机构信息

Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy.

出版信息

Tissue Antigens. 2003 Feb;61(2):177-8. doi: 10.1046/j.0001-2815.2002.00006.x.

DOI:10.1046/j.0001-2815.2002.00006.x
PMID:12694587
Abstract

In this report we describe a new HLA-DRB1 allele, DRB11353, which was initially recognized by a discrepancy between the results obtained with polymerase chain reaction using sequence-specific oligonucleotide (PCR-SSO) and sequence-specific primers (PCR-SSP). Sequence-based typing revealed sequence differences with other known HLA-DRB1 alleles. DRB11353 is identical to DRB1*13011 except for two nucleotide substitutions at nucleotide 84 (C(r)G) and at nucleotide 140 (T(r)A). These differences give rise to two amino acid substitutions at codons 28 and 47 from Asp to Glu and from Phe to Tyr, respectively.

摘要

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