中国西南部纳西族群体中HLA - DRB1、DQB1和DPB1基因多态性
HLA-DRB1, DQB1 and DPB1 polymorphism in the Naxi ethnic group of South-western China.
作者信息
Fu Y, Liu Z, Lin J, Jia Z, Chen W, Pan D, Liu Y, Zhu Y, Chen R, Xu A
机构信息
Department of Biochemistry, Sun Yat-Sen (Zhongshan) University, Guangzhou, China.
出版信息
Tissue Antigens. 2003 Feb;61(2):179-83. doi: 10.1034/j.1399-0039.2003.00012.x.
Polymorphism of HLA-DRB1, DQB1 and DPB1 was revealed with a sequencing-based typing (SBT) method in unrelated healthy volunteers from the Naxi ethnic group. Among the 43 DRB1 alleles detected, the most common allele was DRB112021 with a frequency of 17%, followed by DRB108032, DRB109012 and DRB11404 with frequencies of 8.5%, 7.4% and 7.4%, respectively. Among 23 DQB1 alleles detected, the most frequent DQB1 allele was DQB103011/0309 (21.9%), followed by DQB10502 (16.4%) and DQB105031 (9.6%). For the DPB1 locus, the most common alleles were DPB10501 (25.5%), DPB10402 (14.6%) and DPB102012 (12.0%). The most common DRB1-DQB1-DPB1 haplotype was DRB11404-DQB105031-DPB10402 with a frequency of 5.26%, followed by the DRB108032-DQB106011-DPB11301 (3.51%). The distribution characteristics of the HLA class II alleles revealed that the Naxi ethnic group belonged to the Southern group of Chinese.
采用基于测序的分型（SBT）方法，在纳西族无血缘关系的健康志愿者中揭示了HLA-DRB1、DQB1和DPB1的多态性。在检测到的43个DRB1等位基因中，最常见的等位基因是DRB112021，频率为17%，其次是DRB108032、DRB109012和DRB11404，频率分别为8.5%、7.4%和7.4%。在检测到的23个DQB1等位基因中，最常见的DQB1等位基因是DQB103011/0309（21.9%），其次是DQB10502（16.4%）和DQB105031（9.6%）。对于DPB1基因座，最常见的等位基因是DPB10501（25.5%）、DPB10402（14.6%）和DPB1020,12（12.0%）。最常见的DRB1-DQB1-DPB1单倍型是DRB11404-DQB105031-DPB10402，频率为5.26%，其次是DRB108032-DQB106011-DPB11301（3.51%）。HLA II类等位基因的分布特征表明，纳西族属于中国南方群体。
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