Lu Mengji, Lorentz Thomas
Institut für Virologie, Universitätsklinikum Essen, Essen, Germany.
J Infect Dis. 2003 Apr 15;187(8):1323-6. doi: 10.1086/373902. Epub 2003 Mar 26.
A renal transplant recipient became persistently positive for hepatitis B virus (HBV) despite preexisting anti-hepatitis B surface (HBs) antibodies. The antigenicity and immunogenicity of wild-type (wt) and mutant HBs antigens (Ags) were compared. In contrast to wt HBsAg, genetic vaccination with mutant HBsAgs did not induce anti-HBs. Thus, mutations within HBsAg may enable HBV to escape immunological control.
一名肾移植受者尽管之前存在抗乙型肝炎表面（HBs）抗体，但仍持续出现乙型肝炎病毒（HBV）阳性。对野生型（wt）和突变型HBs抗原（Ag）的抗原性和免疫原性进行了比较。与野生型HBsAg不同，用突变型HBsAg进行基因疫苗接种未诱导产生抗HBs。因此，HBsAg内的突变可能使HBV逃避免疫控制。
