基于多巴胺和左旋多巴的异喹啉对乙醇麻醉的增强作用。
Potentiation of ethanol narcosis by dopamine- and l-DOPA-based isoquinolines.
作者信息
Marshall A, Hirst M
出版信息
Experientia. 1976 Feb 15;32(2):201-3. doi: 10.1007/BF01937765.
PMID:1269611
Abstract
The isoquinolines, salsolinol and 3-carboxysalsolinol, prolong ethanol-induced narcosis in mice. Pretreatment with carbidopa increases the effect of 3-carboxysalsolinol but not of salsolinol. These results suggest that ethanol sleeping-time potentiation by l-LOPA may involve a partial conversion to the isoquinoline in vivo. A central depressant action of salsolinol or the 3-carboxy analogue is suggested.
摘要
异喹啉、四氢异喹啉和3-羧基四氢异喹啉可延长乙醇诱导的小鼠麻醉时间。用卡比多巴预处理可增强3-羧基四氢异喹啉的作用，但对四氢异喹啉无效。这些结果表明，左旋多巴对乙醇睡眠时间的增强作用可能涉及体内部分转化为异喹啉。提示四氢异喹啉或3-羧基类似物具有中枢抑制作用。
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