Shearman G T, Herz A
Psychopharmacology (Berl). 1983;81(3):224-7. doi: 10.1007/BF00427266.
Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgesic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these date do not support a biochemical link between ethanol and opiates.
雄性斯普拉格-道利大鼠在双杠杆食物强化程序中接受训练，以区分生理盐水和合成麻醉性镇痛药芬太尼（0.04毫克/千克）的作用。在获得这种辨别能力后，进行了吗啡、乙醇和一些四氢异喹啉生物碱的泛化试验。大鼠对吗啡的作用呈剂量依赖性泛化，但对乙醇、四氢罂粟碱、salsolinol或3-羧基salsolinol的作用均未泛化到芬太尼辨别刺激上。因此，这些数据不支持乙醇与阿片类药物之间存在生化联系。
