Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects.

Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgesic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these date do not support a biochemical link between ethanol and opiates.