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[腹膜后纤维化——类固醇治疗的临床反应]

[Retroperitoneal fibrosis--clinical response to steroid treatment].

作者信息

Elinav Hila, Hershko Alon, Leibovitch Gil, Naparstek Yaakov

机构信息

Hadassah University Hospital, Jerusalem, Israel.

出版信息

Harefuah. 2003 Mar;142(3):166-9, 240.

Abstract

Retroperitoneal fibrosis is an inflammatory disease, which is either idiopathic or secondary to infection, neoplasm, hemorrhage, aortic aneurysm or drugs. This is a rare disease usually presenting constitutional symptoms, abdominal, back or flank pain and urinary frequency. Treatment includes surgical relief of urethral obstruction and corticosteroids. There is no clear evidence of the beneficial effect of corticosteroids treatment on the course of retroperitoneal fibrosis. We report a patient diagnosed with retroperitoneal fibrosis with an unusual presentation--uncontrolled HTN and renal failure due to renal arteries obstruction, without any abdominal symptoms. This patient responded to steroids and tamoxifen. A review of the literature is also presented.

摘要

腹膜后纤维化是一种炎症性疾病,可为特发性,或继发于感染、肿瘤、出血、主动脉瘤或药物。这是一种罕见疾病,通常表现为全身症状、腹部、背部或侧腹疼痛以及尿频。治疗包括手术解除尿道梗阻和使用皮质类固醇。目前尚无明确证据表明皮质类固醇治疗对腹膜后纤维化病程有有益作用。我们报告一例诊断为腹膜后纤维化的患者,其表现不同寻常——因肾动脉梗阻导致难以控制的高血压和肾衰竭,且无任何腹部症状。该患者对类固醇和他莫昔芬有反应。本文还对相关文献进行了综述。

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