Liu Yun-hai, Yang Qi-dong, Liu Zun-jing, Zhang Le, Zhou Yan-hong, Xu Hong-wei
Xiangya Hospital, Central South University, Changsha 410008, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Feb;24(2):102-5.
To analyze the changes of risk factors in cerebrovascular diseases in cohort-based population after intervention and evaluating the intervention effect.
In 1987, an intervention cohort and a control cohort were selected randomly in urban areas of Changsha. Risk factors in cerebrovascular diseases were investigated in two cohort populations aged over 35 years as baseline indication. Then comprehensive prevention of cerebrovascular diseases was carried out in intervention cohort during 1987 - 2000. After intervention for 14 years, a reexamination was taken in the two groups noted above.
After 14 years, the prevalence of diabetes mellitus, hypertension, mean systolic and diastolic pressure, weight increased from 33.8% to 35.7%, 30 to 129 per 10,000, 128.41 mm Hg to 134.49 mm Hg, 77.78 mm Hg to 78.54 mm Hg, 54.80 kg to 57.78 kg in the intervention group, respectively while the baseline indication increased from 35.9% to 56.8%, 30 to 228 per 10,000, 127.70 mm Hg to 141.80 mm Hg, 78.27 mm Hg to 82.89 mm Hg, 54.92 kg to 59.69 kg in the control one. The changes were of statistical significance in each group except diastolic pressure and the prevalence of hypertension in intervention group, but all the parameters increased significantly in the control group; rate of alcohol intake decreased significantly in two groups, but rate of cigarette smoking decreased with no significance. The changes between two groups were not significant either; the cumulative incidence of stroke was significantly lower in intervention cohort (3.4%) than in control cohort (4.7%).
The risk factors for cerebrovascular diseases (such as hypertension, diabetes mellitus etc.) were increasing along with by aging. Intervention programs can delay the increase of risk factors and down-regulate the incidence of stroke.
分析基于队列人群脑血管病危险因素在干预后的变化情况，并评估干预效果。
1987年在长沙市城区随机选取一个干预队列和一个对照队列。对两个队列中35岁以上人群进行脑血管病危险因素调查作为基线指标。然后在1987 - 2000年期间对干预队列进行脑血管病综合预防。干预14年后，对上述两组进行复查。
14年后，干预组糖尿病患病率、高血压患病率、平均收缩压和舒张压、体重分别从33.8%升至35.7%、万分之30升至万分之129、128.41 mmHg升至134.49 mmHg、77.78 mmHg升至78.54 mmHg、54.80 kg升至57.78 kg，而对照组基线指标分别从35.9%升至56.8%、万分之30升至万分之228、127.70 mmHg升至141.80 mmHg、78.27 mmHg升至82.89 mmHg、54.92 kg升至59.69 kg。除干预组舒张压和高血压患病率外，每组各项变化均有统计学意义，但对照组所有参数均显著升高；两组饮酒率均显著下降，但吸烟率下降无统计学意义。两组间变化也无统计学意义；干预队列中风累积发病率（3.4%）显著低于对照队列（4.7%）。
脑血管病危险因素（如高血压、糖尿病等）随年龄增长而增加。干预方案可延缓危险因素的增加并下调中风发病率。
