Bai Chang-qing, Ni Dian-tao, Li Ning-xiu, Liu Guan-jian, Dong Bi-rong
Department of Pulmonary Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Feb;24(2):130-4.
The goals of this work was to analyse the cost of Shenqi Fuzheng injection-an extraction of a Chinese traditional herbs on reducing adverse effects in lung cancer patients during chemotherapy.
In a randomized cross-over trial, each patient completed two identical cisplatin-based chemotherapy cycles, one with Shenqi Fuzheng injection, another without Shenqi Fuzheng injection. Adverse effects and change scores of quality of life (QOL) during chemotherapy were compared in tow cycles. The direct cost dealing with adverse effect and cost-effectiveness analysis were taken.
One hundred and thirty were enrolled with 123 of whom were evaluable. The patient characteristics were well balanced between the two groups. The chemotherapy cycles with Shenqi Fuzheng injection spent 220.5 more Chinese yuan, but the adverse effect of leukopenia, thrombocytopenia and vomiting were slight different and the change of score of several QOL domains showed significant better as compared to those in another cycle.
Shenqi Fuzheng injection could reduce the severity of toxicity related to chemotherapy and improve the QOL of patients and had some benefits in terms of cost-effectiveness.
本研究旨在分析中药提取物参芪扶正注射液在降低肺癌患者化疗期间不良反应方面的成本。
在一项随机交叉试验中，每位患者完成两个相同的基于顺铂的化疗周期，一个周期使用参芪扶正注射液，另一个周期不使用。比较两个周期化疗期间的不良反应和生活质量（QOL）变化评分。进行了处理不良反应的直接成本和成本效益分析。
共纳入130例患者，其中123例可评估。两组患者的特征均衡。使用参芪扶正注射液的化疗周期多花费220.5元人民币，但白细胞减少、血小板减少和呕吐的不良反应略有不同，几个QOL领域的评分变化与另一个周期相比有显著改善。
参芪扶正注射液可降低化疗相关毒性的严重程度，改善患者的QOL，在成本效益方面有一定益处。
