Barnes M M, Smith A J
Int J Vitam Nutr Res. 1975;45(3):342-8.
The incorporation of 14C-cholesterol into total androgens by testis homogenates and into total androgens and corticosterone by adrenal homogenates was measured in tissues taken from rats deficient in vitamin E, and from rats given vitamin E, from weaning to a maximum of 293 days. The peak of incorporation of 14C into adrenal steroids, androgens and corticosterone, were delayed in the rats deficient in vitamin E, which might suggest a delayed or prolonged period of puberty in vitamin E deficiency. After this period of increased steroidogenesis the deficient rats incorporated consistently less 14C into adrenal steroids and testicular androgens than did the control rats, although the differences were not statistically significant in the experiments described.
在从断奶至最长293天的时间段内，对取自维生素E缺乏大鼠和给予维生素E的大鼠的组织进行检测，测定睾丸匀浆将14C -胆固醇转化为总雄激素的情况，以及肾上腺匀浆将14C -胆固醇转化为总雄激素和皮质酮的情况。维生素E缺乏的大鼠中，14C掺入肾上腺类固醇、雄激素和皮质酮的峰值出现延迟，这可能表明维生素E缺乏时青春期延迟或延长。在这段类固醇生成增加的时期之后，与对照大鼠相比，缺乏维生素E的大鼠将14C掺入肾上腺类固醇和睾丸雄激素的量持续减少，尽管在所描述的实验中差异无统计学意义。
