Jang Chul Ho, Kim Young Ho
Department of Otolaryngology, Wonkwang Medical School, Iksan 570-711, South Korea.
Int J Pediatr Otorhinolaryngol. 2003 May;67(5):531-3. doi: 10.1016/s0165-5876(03)00015-6.
Regulated upon activation, normal T cell-expressed and -secreted (RANTES) is a chemokine which is an effective eosinophil and memory T cell chemoattractant and activator, and eosinophil is an important effector cell in allergic disease. It may contribute to the pathogenesis of otitis media with effusion (OME). Eosinophil cataionic protein (ECP), one of the major components of basic granules of eosinophils which is identified in middle ear effusion (MEE). We measured RANTES and ECP in MEEs of OME to determine whether RANTES is increased in the MEEs of OME with allergy. We also evaluated the correlation between RANTES and ECP to determine the role of RANTES as an eosinophil activator in the pathogenesis in OME with allergy. Both RANTES and ECP in MEE of OME with allergy were significantly higher than controls. There was a significant correlation between the contents of RANTES and ECP. Our results suggest the allergic role of chemokine in the pathogenesis of OME.
活化调节正常T细胞表达和分泌因子（RANTES）是一种趋化因子，是有效的嗜酸性粒细胞和记忆T细胞趋化剂及激活剂，而嗜酸性粒细胞是变应性疾病中的重要效应细胞。它可能参与分泌性中耳炎（OME）的发病机制。嗜酸性粒细胞阳离子蛋白（ECP）是嗜酸性粒细胞基本颗粒的主要成分之一，在中耳积液（MEE）中被发现。我们检测了OME患者MEE中的RANTES和ECP，以确定变应性OME患者的MEE中RANTES是否升高。我们还评估了RANTES与ECP之间的相关性，以确定RANTES作为嗜酸性粒细胞激活剂在变应性OME发病机制中的作用。变应性OME患者MEE中的RANTES和ECP均显著高于对照组。RANTES和ECP的含量之间存在显著相关性。我们的结果提示趋化因子在OME发病机制中的变应性作用。
