[某些吡啶并(2,3 - e)-1,4 -二氮杂卓的制备]
[Preparation of some pyrido (2,3-e)-1,4-diazepines].
作者信息
Carboni S, Da Settimo A, Bertini D, Ferrarini P L, Livi O, Tonetti I
出版信息
Farmaco Sci. 1976 May;31(5):322-33. doi: 10.1002/chin.197637272.
PMID:1269736
Abstract
By treating pyrido (2,3-e)-1,4-diazepinones with alkyl halides, N4-alkylpyrido (2,3-e)-1,4-diazepines were obtained. In addition a number of N1-alkylpyrido (2,3-e)-1,4-diazepines were prepared from alkyltetrahydronaphthyridinones by the Schmidt reaction. Preliminary pharmacological screening of some of these compounds showed no appreciable activity.
摘要
通过用卤代烃处理吡啶并[2,3 - e]-1,4 - 二氮杂卓酮，得到了N4 - 烷基吡啶并[2,3 - e]-1,4 - 二氮杂卓。此外，通过施密特反应由烷基四氢萘啶酮制备了一些N1 - 烷基吡啶并[2,3 - e]-1,4 - 二氮杂卓。对其中一些化合物的初步药理筛选显示没有明显活性。
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