Waki H, Shimizu T, Katahira K, Nagayama T, Yamasaki M, Katsuda S I, Wago H, Okouchi T
Department of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
J Gravit Physiol. 2000 Jul;7(2):P169-70.
Exposure to microgravity induces cardiovascular deconditioning characterized by orthostatic hypotension when astronauts return to the earth. In order to understand the mechanism of cardiovascular deconditioning, it is necessary to clarify the changes in hemodynamics and the cardiovascular regulation system over the period of space flight. The telemetry system applied to freely moving animals will be a useful and appropriate technique for this kind of long term study of the cardiovascular system in the conscious animal during space flight. The purpose of the present study is twofold: firstly, to observe the detailed changes of arterial pressure and heart rate (HR) during microgravity elicited by the parabolic flight in order to study the acute effect of microgravity exposure on the cardiovascular system; and secondly, to test the feasibility of the telemetry system for recording blood pressure, HR and autonomic nervous activities continuously during space flight.
暴露于微重力环境会导致心血管功能失调，宇航员返回地球时会出现体位性低血压。为了了解心血管功能失调的机制，有必要阐明太空飞行期间血液动力学和心血管调节系统的变化。应用于自由活动动物的遥测系统将是一种有用且合适的技术，用于在太空飞行期间对清醒动物的心血管系统进行这种长期研究。本研究的目的有两个：首先，观察抛物线飞行引起的微重力环境下动脉血压和心率（HR）的详细变化，以研究微重力暴露对心血管系统的急性影响；其次，测试遥测系统在太空飞行期间连续记录血压、心率和自主神经活动的可行性。
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