Shimizu T
Dept. of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
J Gravit Physiol. 2000 Jul;7(2):P51-4.
The study on development in altered gravity has been investigated in a wide range of animal species from a molecular level or cell culture to mammalian bodies. However development of the baroreflex has been studied in limited mammalian species even on the ground except the turtle to study diving reflex. The rat or mouse has been selectively used for studying the relationship between development of various functions and gravity especially microgravity, because of the limited body size for the loading space on the space ship, an experimental-animal most often used, and other biological characteristics. We have used the rat and rabbit for investigating the effect of microgravity on the development of the aortic baroflex. In the present paper a few results of our experiments using the rat will be shown and the appropriateness of the rat as a model system for studying the baroflex development in altered gravity will be discussed.
关于重力改变对发育影响的研究已在从分子水平或细胞培养到哺乳动物机体等广泛的动物物种中展开。然而，除了用于研究潜水反射的海龟外，即使在地面条件下，压力感受性反射的发育也仅在有限的哺乳动物物种中进行了研究。由于太空船上的装载空间有限，而大鼠或小鼠体型较小，是最常使用的实验动物，并且具有其他生物学特性，因此它们被选择性地用于研究各种功能的发育与重力尤其是微重力之间的关系。我们使用大鼠和兔子来研究微重力对主动脉压力感受性反射发育的影响。在本文中，将展示我们使用大鼠进行实验的一些结果，并讨论将大鼠作为研究重力改变时压力感受性反射发育的模型系统的适用性。
